In accordance with the strategy of improving the quality of food products until 2023, a comparative analysis of the dynamics of consumption of basic food products and monitoring of food raw materials, food products in the Chelyabinsk region in the dynamics of 7 years was carried out and a tendency to decrease the consumption of nutritionally valuable products was noted. The results of monitoring the quality of food products by chemical and microbiological indicators indicate that there is a tendency to decrease the specific weight of samples that do not correspond to sanitary and microbiological indicators.
Thus, there is a need to improve the methodological base, methodological approaches for sampling and conducting food research during the socio-hygienic monitoring of food quality and safety.

The article provides data on the assessment of the clinical efficacy of long-term use of a selective inhibitor of phosphodiesterase-4 (roflumilast) in patients with chronic obstructive pulmonary disease in combination with metabolic syndrome. The study included 106 patients with COPD in combination with metabolic syndrome. The main parameters for assessing the effectiveness were: the frequency and duration of exacerbations, the dynamics of the severity of productive cough, the severity of dyspnea on the mMRC scale, CAT test, FEV1, the levels of pro-inflammatory markers — C-reactive protein, interleukin-6, leptin. Results and conclusions: the addition of roflumilast to the standard bronchodilator therapy of patients with bronchitic COPD phenotype in combination with metabolic syndrome helps to reduce the frequency and duration of exacerbations, has a positive effect on the severity of the main clinical symptoms, helps to reduce the activity of the systemic inflammatory response and improve the prognosis for this category of patients.

The article presents the features of the transition to distance learning due to the introduction of quarantine measures in connection with the spread of COVID-19, considers the advantages and disadvantages of distance learning, assesses the dynamics of the performance indicators of students of a medical university. It was revealed that when organizing distance learning there are technical problems: interruptions in the work of online platforms, lack of proper software for students and teachers, as well as the lack of direct contact between students and teachers. Among the advantages are saving time and money for moving, comfortable learning in a familiar home environment, reducing stress levels, the ability to choose the optimal pace of mastering the material, the ability to plan the daily routine, changing the mode of communication with the teacher during school and extracurricular time.

Systemic lupus erythematosus (SLE) is a systemic autoimmune rheumatic disease of unknown etiology, characterized by overproduction of organ-specific autoantibodies to various components of the cell nucleus and the development of immune-inflammatory damage to internal organs. Early diagnosis and timely therapy largely determine the prognosis of the disease. We present a clinical case of an atypical onset of SLE with bilateral carpal tunnel syndrome.

COVID infection is associated with a high incidence of thrombotic conditions, including the patients who have got active anticoagulant therapy. The thoracoscopic sympathectomy can be used in cases of distal thrombosis, inability to restore the main blood flow, as well as in cases of ineffectiveness of therapy. The article described a case of surgical treatment of ulnar artery occlusion that developed in a patient with COVID infection. This case had a good clinical outcome. The surgery stopped trophic disorders in the fingers of the left hand and a patient avoided amputation of the fingers.

Helicobacter pylori (H. pylori) infection leads to various diseases such as gastric and duodenal ulcers, chronic gastritis and malignant diseases, including MALT lymphoma and stomach cancer. To date, various factors of pathogenicity and virulence of the H. pylori bacterium have been studied. The interaction of infection with host cells leads to the induction of inflammatory responses through the release of cytokines, activation of apoptosis or proliferation, which leads to inflammation and dysfunction of the epithelial barrier. This process can facilitate the movement of H. pylori virulence factors and inflammatory mediators into the bloodstream and promote or enhance the development of a systemic inflammatory response and the possible clinical effects of H. pylori infections outside the stomach. The purpose of this review is to clarify the available data on the relationship of H. pylori infection with diseases of the cardiovascular, nervous, endocrine systems, autoimmune diseases, and some other pathologies outside the digestive system.