Aim: to consider the options for the course, diagnosis and treatment of acute portal vein thrombosis.

   Materials and methods: PubMed, RSCI, Google Scholar search engine, and reference lists were used to search for scientific publications. Articles corresponding to the purpose of the review were selected for the period from 1999 to 2021 according to the following terms: “acute portal vein thrombosis”,  “acute mesenteric ischemia”, “pathogenesis”, “diagnosis”, “treatment”. Inclusion criteria were limited to acute portal vein thrombosis in patients without cirrhosis and liver malignancy.

   Results and conclusions. Acute portal vein thrombosis in patients without cirrhosis and liver malignancy is rare. The main role in the diagnosis is played by imaging methods (duplex ultrasound scanning, multislice computed and magnetic resonance imaging). Timely diagnosis is necessary to prevent complications such as intestinal infarction, sepsis, cavernous transformation of the portal vein. Treatment of acute portal vein thrombosis consists in recanalization of the thrombosed vein, prevention of thrombus spread to mesenteric vessels and intestinal infarction, as well as correction of concomitant diseases.

   The aim of the work: to analyze childhood disability in Russia by years, gender differences and classes of diseases.

   Materials and methods. An analysis was made of the number of child disabilities, gender and age structure in the data according to official reports: the Federal State Statistics Service of Russia, the Ministry of Labor and Social Protection of the Russian Federation, the state information system “Federal Register of Disabled Persons” for the period from 2017 to 2020.

   Results and conclusion. In the structure of diseases in children with disabilities, 24.3 % of cases are mental and behavioral disorders; 23.2 % — diseases of the nervous system; 17.7 % — congenital anomalies, deformities and chromosomal disorders; diseases of the endocrine system — 7.8 %; ear diseases — 4.7 %; diseases of the eye and adnexa — 4.6 %; diseases of the musculoskeletal system — 3.7 %; respiratory diseases — 3.7 %; the share of other diseases accounted for no more than 10.3 %. Priority should be given to the development of the medical genetic service; improvement of antenatal and perinatal care; introduction of screening programs for various types of pathology.

   Relevance. The mortality of the working-age population is one of the indicators of the state of national security of the country, and the task of reducing the mortality rate of this population is one of the most urgent tasks of state health policy. The health status of the rural working-age population is characterized by unfavorable demographic trends, trends in the growth of morbidity and mortality, which justifies the need to develop preventive programs aimed at reducing the mortality of the working-age population in a strategic perspective. The developmentof these programs  cannot be carried out without analyzing the mortality of the working-age population, determining the priority classes of diseases that form the main causes of death, as well as studying the forecast of mortality in the working-age population, which substantiates the relevance of the study.

   The purpose of the study is to assess the forecast of the health status of the rural working-age population of the administrative district of the Chelyabinsk region based on the analysis of demographic indicators.

   Methods: mathematical and statistical; analytical, method of mathematical modeling, based on the construction of a trend line.

   Research results. A forecast was obtained for the preservation of the dynamics of the decline in the number of working-age population in a rural area, which is due to high rates of mortality among the able-bodied population. By the method of mathematical modeling, a forecast of the growth dynamics for the medium term of the mortality rate of the population of the region of working age, including the mortality rate by cause of death by disease classes “External causes of death”, “Some infectious and parasitic diseases” was obtained. The data obtained indicate the insufficient effectiveness of measures aimed at reducing the mortality of the working-age population at the municipal and regional levels, and justify the need to analyze the causes of inefficiency and develop new organizational technologies for managing the mortality of the able-bodied population living in rural areas.

   Conclusions. The application of the mathematical modeling method made it possible to obtain the predicted dynamics of the mortality rate of the working-age population of the district and region, which can be used in the development of specialized preventive programs aimed at reducing the mortality of the rural population of working age in the strategic future, as well as in the development of measures aimed at improving the organization of the provision of medical care for this category of the population and the preservation of labor resources.

   The aim of the work is to give a medical and social characteristic of patients treated for chronic venous diseases (CVD) of the lower extremities in an outpatient phlebological center.

   Materials and methods. A selective retrospective analysis of medical records for 2015, 2018 and 2021 was carried out in 303 randomly selected  patients. For satisfaction assessments additionally analyzed 509 questionnaires filled out by patients of the center.

   Results. Among patients with CVD, 75 % were women (mean age = 50.2 years). 82 % were persons of working age, among them patients with higher education made up 48 %. At the initial phlebologist's appointment and after ultrasound, objective signs of CVD were not detected in an average of a fifth of patients. The most frequent classes in the registration of CVD were C2 and C3 (2015 — 77.8 %; 2018 — 74.4 %; 2021 — 67.6 %). The share of running classes (C4–C6) did not exceed 10 %. The proportion of those treated with telangioectases and reticular veins (C1) is about 20 %. Among the appointments after the examination of specialists, the most frequent was the recommendation to perform EVLT of subcutaneous veins: 2015 — 50.6 %; 2018 — 36.7 %; 2021 — 52.1 %. The proportion of patients satisfied with the results of treatment in different positions was 87–100 %.

   Conclusion. The data obtained will be used to improve the organization of receptions of phlebologists and the work of medical staff.

   The purpose of the work: to consider the development of the organization of medical care for workers of industrial enterprises on the example of the medical unit of a metallurgical plant in the city of Chelyabinsk.

   Materials and methods: authors' publications, historical documents, content analysis method.

   Results. Described presents the stages of development of a medical institution. The formation of the hospital from 1942 to 1990 is described. It is described how from a small outpatient clinic located in a barrack, a multidisciplinary hospital was formed, serving the population of the Metallurgical district of Chelyabinsk. Attention is paid to the activities of chief
doctors, specialists of the medical unit, who worked in the hospital from the moment of foundation until the 90^s of the last century and made a great contribution to its development.

   Conclusions. The history of the creation and development of one of the largest medical institutions of industrial medicine is an example of a comprehensive solution to the problem of preserving the health of workers at large industrial enterprises, the interest in improving the availability and quality of medical care on the part of not only the healthcare system, but also the heads of industrial enterprises. The work of medical workers in these medical organizations contributed to the successful solution of the nationwide task of maintaining and improving the health of the working population.

   The aim: to evaluate the diagnostic value of intraoperative ultrasound during surgery in patients with oncological pathology.

   Materials and methods. The article is devoted to the analysis of intraoperative ultrasound examinations performed by patients with detected tumor lesions of various organs in the Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine for 5 years.

   Results and conclusions. The most popular intraoperative ultrasound examinations, distribution by age, gender, frequency of detection of various focal liver pathology.

   The aim: to consider aspects of detection and treatment of patients with GAVE syndrome.

   Materials and methods. The article is devoted to the correction of iron deficiency in ectasia of the vessels of the antrum. Theories of pathogenesis, endoscopic picture and clinical case of a patient with GAVE syndrome are described.

   Results and conclusions. Gastric antral vascular ectasia (GAVE) is a rare but clinically important cause of chronic gastrointestinal bleeding. The etiology of GAVE syndrome is not fully understood and remains controversial. The diagnosis is based on the endoscopic picture, which is characterized by bright areas of hyperemia in the form of stripes radiating from the pylorus to the antrum and resembling a watermelon. The clinical picture can vary from iron deficiency anemia, hidden blood loss, melena to hematemesis. Therapy is limited to a surgical or endoscopic approach, as most medical treatments have shown inconsistent results. Here, we review the efficacy of these treatment options and methods for identifying patients with GAVE syndrome.

   The aim of the study was to develop a method for predicting blastocyst implantation and live birth in assisted reproductive technology programs in women of late reproductive age with tubal-peritoneal infertility based on the determination of immunohistochemical determinants of the endometrial pattern.

   Materials and methods. The results of IVF and IVF/ICSI programs using own oocytes were analyzed in 68 patients of older reproductive age with tubal-peritoneal infertility factor. Histological examination of endometrial samples (n=68) was performed on day 7 after ovulation in the cycle preceding
assisted reproductive technologies (ART). The expression of vitamin D (VDR) and HOXA11 receptors in endometrial stromal cells was evaluated by immunohistochemistry.

   The results of the study. The expression levels of VDR (<8.7 %) and HOXA11 (<6.1 %) favorable for successful implantation of the blastocyst were determined, live births — VDR (<8.3 %) and HOXA11 (<6.1 %). Mathematical models have been developed that allow predicting implantation (with an index >0.17) and live birth (index >0.19) with high diagnostic accuracy based on an assessment of the expression of the expression variables VDR and HOXA11 stroma.

   Conclusion. The effectiveness of using endometrial markers VDR and HOXA11 as potential predictors of the effectiveness of ART programs is confirmed by prognostic models and patents of the Russian Federation.

   The aim. The article presents the features of teaching foreign students using an intermediary language, discusses the difficulties and controversial points, and gives a comparative assessment of the dynamics of academic performance of foreign and Russian-speaking students of the medical faculty of the Medical University.

   Materials and methods. It is revealed that there are disciplinary problems in the organization of teaching with the use of an intermediary language.

   Results and conclusions. Among the advantages is a small number of students in the group, which allows for the full use of a multi-sided form of communication not only in practical, but also in lecture classes.