The article analyzes the epidemiological situation of HIV infection in the Chelyabinsk region in dynamics for 2000–2019 among the main risk groups and the general population. Based on the data obtained, the leading factors and population groups are identified that will determine the further development of the spread of HIV infection in the region. In accordance with the identified regional characteristics of the spread of HIV infection, priority directions are proposed for the organization of a monitoring survey of the population and preventive work.

Objective of this study was to assess the association of G735A mutation in the DPYD gene detected by PCR in patients who are prescribed 5-fluorouracil or capecitabine with the development of nephrotoxicity, hepatotoxicity, and hematotoxicity. Hematotoxicity was assessed using a general blood test. Assessment of hepatotoxicity and nephrotoxicity was carried out according to the general biochemical analysis of blood (total bilirubin, AST, ALT, urea, creatinine). All indicators were evaluated before the start of therapy and after completion of the course of therapy. At this stage of the study, the genes associated with the toxicity of fluorouracil and capecitabine were not found among the examined patients, and there were also no critical manifestations of toxicity after using these drugs according to clinical and laboratory tests. This study is considered as a pilot. However, given the low prevalence of the frequency of occurrence of mutant alleles, using of this type of testing in the region may be inappropriate.

The author's task in writing the article was to systematize the current literature on the nature of involvement of the gastrointestinal tract in the pathological process in COVID-19, to draw the attention of the medical audience to the features of the supervision of gastroenterological patients during the pandemic.

Primary health care is the backbone of the health care delivery system. The problem of improving primary health care, including in rural areas, has become a priority and is of national importance. The development of measures aimed at improving the organization of the provision of primary health care to the rural population, increasing the availability and quality of medical care and improving medical and demographic indicators is an urgent scientific and practical problem.
Methodological recommendations contain general organizational and methodological approaches to organizing the provision of primary health care to the population of rural areas, addressed to the heads of medical organizations providing primary health care, deputy heads for the polyclinic section of work, heads and medical workers of general practitioners' centers, medical outpatient clinics, feldsher-obstetric points.
The methodological recommendations provide a methodological justification and development of measures aimed at increasing the availability and improving the system of organizing the provision of primary health care according to the territorial-district principle to the population of rural areas of the Chelyabinsk region.
When developing methodological recommendations, the existing normative legal acts regulating the provision of primary health care to the population were analyzed and summarized, the current state of the organization of primary health care in the Chelyabinsk region was analyzed, issues were identified for which there is no legal regulation. An organizational model of a rural medical district has been developed with the aim of improving the organization of the provision of primary health care to the rural population according to the territorial-district principle.

The paper addresses the matters of supporting students with physical disabilities as a vital component of the educational system of the university. The research reflects certain steps of the process and directions in which the support of the mentioned group of students should be carried out. The authors offer their experience of holding a competitive professional skills championship “Abilimpics” among people with disabilities. The degrees of significance of supporting the participants of “Abilimpics” are also mentioned in the paper.