D. Sinitsyn was born on 25.01.1921. He went through a difficult path from a rural boy to a professor of medicine-the organizer of the scientific school of therapists, known in our country and abroad. He participated in the Great Patriotic War. The essay reflects the outstanding contribution of a remarkable Person of high spiritual and moral culture, a Doctor, Scientist, and public figure to the development of South-Urals State Medical University, the training of medical personnel, healthcare, and the social sphere of the Chelyabinsk region.

The results of monitoring the state of atmospheric air, as well as climatic features of a large industrial center of the Southern Urals are presented. An assessment of the risk to the health of the child population from exposure to chemicals detected in the atmospheric air of the city is given. A non-carcinogenic risk was established from exposure to copper, formaldehyde, benz(a)pyrene, manganese, and suspended solids. It has been established that unidirectional pollutants affect not only the respiratory system, the immune system, the central nervous, hematopoietic, cardiovascular systems, but also the reproductive system. A retrospective analysis of congenital malformations for the period 2017–2019 was carried out based on archival materials of the Chelyabinsk regional pathoanatomical bureau and maternity hospitals of city clinical hospitals. The dynamics, prevalence and structure of congenital malformations in children have been studied. It was found that the incidence of congenital anomalies in the Chelyabinsk region exceeds the average for the Russian Federation with a tendency to an increase in the number of cases of congenital malformations. In the structure of congenital malformations, the first place is taken by malformations of the cardiovascular system (24.1%), the second place is taken by congenital malformations of the central nervous system (20.5%), and chromosomal abnormalities are in third place (17.9%). Attention is drawn to multiple malformations, the proportion of which is 15.1%; they occur with a frequency exceeding the data of the International European Register — 3.8 per 1000 births, versus 0.9–2.4 EUROCAT.

The aim of the research was to reveal the frequency of latent arterial hypertension (LAG) and associated cardiovascular risk among practically healthy men aged 40–49 years with normal (NAD) and high normal BP (HNAD).
Material and methods. A one-time continuous examination of 332 men aged 40–49 years without signs of hypertension was performed according to the office blood pressure measurement with different blood pressure levels. Daily monitoring of blood pressure (BPM), assessment of risk factors for cardiovascular complications (FV MTR), and cardiovascular remodeling were performed.
Results. The prevalence of SAG among men aged 40–49 years with a continuous study was 19%, among the group with the HNAD — 24%, in the group with NAD 13%. In patients with HNAD, the presence of signs of AH according to BPM is recorded in a quarter of patients and is associated with the presence of structural and functional changes in the heart (LVH presence, an increase in the left atrium, a violation of systolic and diastolic function according to tissue dopplerography), vessels (an increase in TIM, relaxation disturbance Brachial artery) and kidney condition (increase in creatinine, a decrease in glomerular filtration rate). In patients with NAD, the presence of signs of AH according to BPM is not associated with FH MFD, features of the lipid metabolic profile and defeat of target organs.
Conclusions. BPM is a method of stratifying risk and selecting patients for in-depth study precisely in the case of a high normal office level of blood pressure. In the group of patients with normal arterial pressure, BPM is not a method of risk stratification and its conduct is clearly redundant.

Purpose: scientific substantiation of the holistic model of the continuum of human health quality in ontogenesis as a system for improving the prevention of non-communicable diseases. The analysis of the reasons for the lack of effectiveness of programs for the prevention of non-communicable diseases is carried out. A holistic model of the continuum of health quality in human life is proposed. Qualitology of human health is considered as a scientifically based innovative project of the system of health promotion and effective prevention of non-communicable diseases.

The rate of infant and child mortality is one of the main indicators of the health and well-being ofthe country's population, and an important factor in determining priorities in the field of health care and the distribution of funds for social purposes.
The study of the dynamics of the infant mortality rate, including in rural areas, is an urgent scientific and practical problem. The relevance of the topic under study is supported by the strengthening of the social orientation of state programs at the federal and regional levels, in which the indicators of this indicator are determined.
The article presents an analysis of the level, structure and dynamics of infant mortality in the Chelyabinsk region, including in rural areas, for the period from 2008 to 2018, in comparison with similar indicators in the Russian Federation. The priority classes of diseases that form the main causes of mortality in children under 1 year of age have been determined. The structure of perinatal mortality by age is analyzed. The actually achieved values of the infant mortality rate have been evaluated in comparison with the indicators of the National and Regional Project “Development of Children's Health Care, Including the Creation of a Modern Infrastructure for Providing Medical Care to Children”. The directions of prevention and reduction of the infant mortality rate have been determined.
It was established that the infant mortality rate in the region as a whole decreased by 1.5 times, and in rural areas by 1.3 times, while the infant mortality rate in the region throughout the entire study period, including in rural areas, was higher than the indicator for the Russian Federation. A decrease in the level of infant mortality was established for almost all priority classes of diseases that form the main causes of mortality in children under 1 year of age.
Timely analysis of infant mortality makes it possible to develop measures aimed at preventing and reducing morbidity and mortality in children, to assess the effectiveness of socio-economic and medical-sanitary measures aimed at protecting the health of mothers and children.

The definition, goals, objectives, advantages of distance media education, its structural elements andforms are formulated. The characteristics of the massive open online course (MOOC) and created in the Medical and biological University of innovation and continuous education of the State Research Center — Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency multifunctional information media center.