Latent arterial hypertension and its relationship with cardiovascular risk in men with normal and high normal blood pressure levels
Abstract
The aim of the research was to reveal the frequency of latent arterial hypertension (LAG) and associated cardiovascular risk among practically healthy men aged 40–49 years with normal (NAD) and high normal BP (HNAD).
Material and methods. A one-time continuous examination of 332 men aged 40–49 years without signs of hypertension was performed according to the office blood pressure measurement with different blood pressure levels. Daily monitoring of blood pressure (BPM), assessment of risk factors for cardiovascular complications (FV MTR), and cardiovascular remodeling were performed.
Results. The prevalence of SAG among men aged 40–49 years with a continuous study was 19%, among the group with the HNAD — 24%, in the group with NAD 13%. In patients with HNAD, the presence of signs of AH according to BPM is recorded in a quarter of patients and is associated with the presence of structural and functional changes in the heart (LVH presence, an increase in the left atrium, a violation of systolic and diastolic function according to tissue dopplerography), vessels (an increase in TIM, relaxation disturbance Brachial artery) and kidney condition (increase in creatinine, a decrease in glomerular filtration rate). In patients with NAD, the presence of signs of AH according to BPM is not associated with FH MFD, features of the lipid metabolic profile and defeat of target organs.
Conclusions. BPM is a method of stratifying risk and selecting patients for in-depth study precisely in the case of a high normal office level of blood pressure. In the group of patients with normal arterial pressure, BPM is not a method of risk stratification and its conduct is clearly redundant.
About the Authors
E. A. GrigorichevaRussian Federation
Chelyabinsk
Yu. L. Bondareva
Russian Federation
V. V. Evdokimov
Russian Federation
Chelyabinsk
References
1. Pickering T. G., Davidson K., Gerin W. et al. Masked hypertension // Hypertension. 2002. Vol. 40, № 6. P. 795–796.
2. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) // Journal of Hypertension. 2013. Vol. 31, № 7. P. 1281–1357.
3. Liu J. E., Roman M. J., Pini R. et al. Cardiac and arterial target organ damage in adults with elevated ambulatory and normal office blood pressure // Ann. Intern. Med. 1999. Vol. 131, № 8. P. 564–572.
4. Mancia G., Facchetti R., Bombelli M. et al. Long-term risk of mortality associated with selective and combined elevation in office, home, and ambulatory blood pressure // Hypertension. 2006. Vol. 47, № 5. P. 846–853.
5. Ohkubo T., Kikuya M., Metoki H. et al. Prognosis of “masked” hypertension and “white-coat” hypertension detected by 24-h ambulatory blood pressure monitoring 10-year follow-up from the Ohasama study // J. Am. Coll. Cardiol. 2005. Vol. 46, № 3. P. 508–515.
6. Angeli F., Reboldi G., Verdecchia P. Masked hypertension: evaluation, prognosis, and treatment // Am. J. Hypertens. 2010. Vol. 23, № 9. P. 941–948.
7. Pierdomenico S. D., Cuccurullo F. Prognostic value of white-coat and masked hypertension diagnosed by ambulatory monitoring in initially untreated subjects: an updated meta-analysis // Am. J. Hypertens. 2011. Vol. 24, № 1. P. 52–58.
8. Sega R., Trocino G., Lanzarotti A., Carugo S. et al. Alterations of cardiac structure in patients with isolated office, ambulatory, or home hypertension: Data from the general population (Pressione Arteriose Monitorate E Loro Associazioni [PAMELA] Study) // Circulation. 2001. Vol. 104, № 12. P. 1385–1392.
9. Fagard R. H., Cornelissen V. A. Incidence of cardiovascular events in white-coat, masked and sustained hypertension versus true normotension: a meta-analysis // J. Hypertens. 2007. Vol. 25, № 11. P. 2193–2198.
10. Bobrie G., Clerson P., Ménard J. Masked hypertension: a systematic review // J. Hypertens. 2008. Vol. 26, № 9. P. 1715–1725.
11. Verberk W. J., Kessels A. G., de Leeuw P. W. Prevalence, causes, and consequences of masked hypertension: a meta-analysis // Am. J. Hypertens. 2008. Vol. 21, № 9. P. 969–975.
12. Shimbo D., Newman D. J., Joseph E., Schwartz J. E. Masked hypertension and prehypertension: diagnostic overlap and interrelationships with left ventricular mass: the masked hypertension study // Am. J. Hypertens. 2012. Vol. 25, № 6. P. 664–671.
13. Franklin S., Wong N. D. The complexity of masked hypertension: diagnostic and management challenges // Curr. Hypertens. Rep. 2014. Vol. 16, № 9. P. 474.
14. Васюк Ю. А., Котовская Ю. В., Кобалава Ж. Д. Суточное мониторирование и самоконтроль артериального давления: новые акценты рационального использования // Кардиология: новости, мнения, обучение. 2013. № 1. С. 43–53.
15. Горбунов В. М. Суточное мониторирование артериального давления: современные аспекты. М. : Логосфера, 2015. 240 с.
16. Booth J. N., Muntner P., Diaz K. M. et al. Evaluation of Criteria to Detect Masked Hypertension // J. Clin. Hypertens. (Greenwich). 2016. Vol. 18, № 11. P. 1086–1094.
17. Pickerihg T. G., Eguchi K., Kario K. Masked hypertension: a review // Hypertens. Res. 2007. Vol. 30, № 6. P. 479–488.
18. Trudel X., Brisson C., Larocque B., Milot A. Masked hypertension: different blood pressure measurement methodology and risk factors in a working population // J. Hypertens. 2009. Vol. 27, № 8. P. 1560–1567.
19. Cuspidi C., Negri F., Sala C., Mancia G. Masked hypertension and echocardiographic left ventricular hypertrophy: an updated overview // Blood Press. Monit. 2012. Vol. 17, № 1. P. 8–13.
Review
For citations:
Grigoricheva E.A., Bondareva Yu.L., Evdokimov V.V. Latent arterial hypertension and its relationship with cardiovascular risk in men with normal and high normal blood pressure levels. Title in english. 2021;16(1):13-20. (In Russ.)