Dynamics of the lipid spectrum of the blood serum in women during postoperative radiation therapy for endometrial cancer
Abstract
Aim: to estimate the dynamics of the lipid spectrum of blood serum in comparison with the level of circulating products of lipid peroxidation, the concentration of cytokines and the functional state of the liver in women during radiation therapy after surgical treatment of endometrial cancer.
Materials and methods. As part of a cohort prospective study, changes in the lipid profile that develop during the first two weeks of radiation therapy were studied in 24 patients who underwent extended extirpation of the uterus with appendages for endometrial cancer. Additionally, the content of circulating products of lipid peroxidation and cytokines (TNF-α, IL-1β, IL-4, IL-6), as well as indicators of the functional state of the liver, were evaluated.
Results. After 14 days from the start of external pelvic radiation therapy, a significant decrease in the content of total cholesterol (by 12%; p=0.005) and low-density lipoprotein cholesterol (by 10%; p=0.004) was noted in the blood serum of patients. This was accompanied by a decrease in the coefficient of atherogenicity by 0.3% (p=0.011). At the same time, there was an increase in the level of heptane-soluble end products of lipid peroxidation (Schiff bases) by 33% of the initial level (p=0.04). Radiation therapy had no effect on the concentration of circulating cytokines and the functional state of the liver.
About the Author
A. P. Alekseeva
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
Россия
Россия
Chelyabinsk
References
1. Wilkins, E. European cardiovascular disease statistics 2017 / E. Wilkins, L. Wilson, K. Wickramasinghe [и др.]. – Текст : электронный. – URL: https://www.ehnheart.org/images/CVD-statistics-report-August-2017.pdf (дата обращения: 29.01.2022).
2. Mensah, G. A. The global burden of cardiovascular diseases and risk factors: 2020 and beyond / G. A. Mensah, G. A. Roth, V. Fuster // Journal of the American College of Cardiology. – 2019. – Т. 74, № 20. – С. 2529–2532.
3. Сергиенко, И. В. Дислипидемии, атеросклероз и ишемическая болезнь сердца: современные аспекты патогенеза, диагностики и лечения / И. В. Сергиенко, А. А. Аншелес, В. В. Кухарчук. – Москва : Патисс, 2018. – 242 с.
4. Потешкин, Ю. Атеросклероз / Ю. Потешкин // Актуальная эндокринология. – 2018. – № 3. – С. 32.
5. Ахмедов, В. А. Современные взгляды на факторы возникновения и прогрессирования атеросклероза / В. А. Ахмедов, А. С. Шевченко, А. С. Исаева // Русский медицинский журнал. Медицинское обозрение. – 2019. – Т. 3, № 1–2. – С. 57–62.
6. Дутова, С. В. Цитокины и атеросклероз — новые направления исследований / С. В. Дутова, Ю. В. Саранчина, М. Р. Карпова [и др.] // Бюллетень сибирской медицины. – 2018. – № 4. – С. 199–208.
7. Galdiero, M. R. Cancer inflammation and cytokines / M. R. Galdiero, G. Marone, A. Mantovani // Cold Spring Harbor perspectives in biology. – 2018. – Т. 10, № 8. – С. a028662. – doi: 10.1101/cshperspect.a028662
8. Libby, P. Inflammation: a common contributor to cancer, aging, and cardiovascular diseases — expanding the concept of cardio-oncology / P. Libby, S. Kobold // Cardiovascular research. – 2019. – Т. 115, № 5. – С. 824–829. – doi: 10.1093/cvr/cvz058
9. Плотникова, Е. Ю. Дислипидемия — метаболическая проблема печени, терапевтические стратегии / Е. Ю. Плотникова // Гастроэнтерология Санкт-Петербурга. – 2018. – № 4. – С. 8–15.
10. Guo, S. Cholesterol homeostasis and liver X receptor (LXR) in atherosclerosis / S. Guo, L. Li, H. Yin // Cardiovascular & hematological disorders drug targets (Formerly Current drug targets. Cardiovascular & haematological disorders). – 2018. – Т. 18, № 1. – С. 27–33.
11. Wang, H. H. Cholesterol and lipoprotein metabolism and atherosclerosis: recent advances in reverse cholesterol transport / H. H. Wang, G. Garruti, M. Liu [и др.] // Annals of hepatology. – 2017. – Т. 16, прил. 1. – С. S27–S42.
12. Волчегорский, И. А. Сопоставление различных подходов к определению продуктов перекисного окисления липидов в гептан-изопропанольных экстрактах крови / И. А. Волчегорский, А. Г. Налимов, Б. Г. Яровинский [и др.] // Вопросы медицинской химии. – 1989. – № 1. – С. 127–131.
13. Львовская, Е. И. Спектрофотометрическое определение конечных продуктов перекисного окисления липидов / Е. И. Львовская, И. А. Волчегорский, С. Е. Шемяков [и др.] // Вопросы медицинской химии. – 1991. – Т. 37, № 4. – С. 92–94.
14. Ustundag, Y. Relationship between C-reactive protein, systemic immune-inflammation index, and routine hemogram-related inflammatory markers in low-grade inflammation / Y. Ustundag, K. Huysal, S. K. Gecgel [et al.] // International Journal of Medical Biochemistry. – 2018. – Т. 1, № 1. – С. 24–28.
15. Abbas, N. Kupffer cells mediate the recruitment of hepatic stellate cells into the localized liver damage / N. Abbas, A. Getachew, K. You [и др.] // Biochemical and Biophysical Research Communications. – 2020. – Т. 529, № 2. – С. 474–479.
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For citations:
Alekseeva A.P. Dynamics of the lipid spectrum of the blood serum in women during postoperative radiation therapy for endometrial cancer. Continuing Medical Education and Science. 2022;17(1):36-38. (In Russ.)
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