Results of combined treatment of local advanced colon cancer using intraoperative photodynamic therapy

Relevance. Colorectal cancer is one of the most common oncological diseases in Russia. For its treatment, the surgical method is most often used exclusively, but its combination with complex antitumor methods of influencing the area of the surgical field allows to reduce the risk of sudden relapse and peritoneal carcinomatosis. The Aim of the study. This work studies a combined method for the treatment of locally advanced colon cancer using an intraoperative laser photodynamic therapy with the Photolon photosensitizer. Materials and methods. 38 patients were divided into two comparable groups: the control group included 18 patients who had only surgical treatment, the experimental group consisted of 20 patients who additionally had intraoperative photodynamic therapy. PDT included: the photosensitizer injection, laser irradiation and photodynamic diagnostics. PDD was carried out by the absorption method, implemented in our own complex, and was used to develop tactics for irradiating various tissues. Results. The obtained primary and long-term treatment results show that all indicators (except for the duration of the operation) in the experimental group are better than in the control group, and such important indicators as mortality, recurrence, purulent complications and persistent remission are significantly better in the experimental group with a high level of significance. Conclusion. Intraoperative photodynamic therapy of locally advanced colon cancer with Photolon under photodynamic control significantly improves the results of complex treatment of patients with this pathology.

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