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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cmedas</journal-id><journal-title-group><journal-title xml:lang="ru">Непрерывное медицинское образование и наука</journal-title><trans-title-group xml:lang="en"><trans-title>Continuing Medical Education and Science</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2949-6292</issn><issn pub-type="epub">3033-585X</issn><publisher><publisher-name>AGU</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">cmedas-81</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ НАУЧНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Особенности поражения желудочно-кишечного тракта при COVID-19 (обзор актуальной литературы и собственные наблюдения)</article-title><trans-title-group xml:lang="en"><trans-title>Features of gastrointestinal tract lesions in COVID-19 (review of current literature and own observations)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сарсенбаева</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Sarsenbayeva</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сарсенбаева Айман Силкановна, доктор медицинских  наук, профессор кафедры терапии Института дополнительного профессионального образования</p><p>454092, г. Челябинск, ул. Воровского, 64; тел. +7 351 742-82-57</p></bio><bio xml:lang="en"><p>Chelyabinsk</p></bio><email xlink:type="simple">aiman-ss@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Южно-Уральский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>South-Urals State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>05</day><month>08</month><year>2023</year></pub-date><volume>15</volume><issue>4</issue><fpage>14</fpage><lpage>18</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сарсенбаева А.С., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Сарсенбаева А.С.</copyright-holder><copyright-holder xml:lang="en">Sarsenbayeva A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cmedas.elpub.ru/jour/article/view/81">https://cmedas.elpub.ru/jour/article/view/81</self-uri><abstract><p>Задачи автора при написании статьи: провести систематизацию современного литературного материала о характере вовлечения желудочно-кишечного тракта в патологический процесс при COVID-19, обратить внимание врачебной аудитории на особенности курации пациентов гастроэнтерологического профиля в период пандемии.</p></abstract><trans-abstract xml:lang="en"><p>The author's task in writing the article was to systematize the current literature on the nature of involvement of the gastrointestinal tract in the pathological process in COVID-19, to draw the attention of the medical audience to the features of the supervision of gastroenterological patients during the pandemic.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>желудочно-кишечный тракт</kwd><kwd>кишечник</kwd><kwd>воспалительные заболевания кишечника</kwd><kwd>печень</kwd><kwd>COVID-19</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bowel</kwd><kwd>inflammatory bowel diseases</kwd><kwd>COVID-19</kwd><kwd>liver</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Wang D., Hu B., Hu C. et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China // JAMA. 2020. Vol. 323, № 11. P. 1061–1069.</mixed-citation><mixed-citation xml:lang="en">Wang D., Hu B., Hu C. et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China // JAMA. 2020. Vol. 323, № 11. P. 1061–1069.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Dong E., Du H., Gardner L. An interactive web-based dashboard to track COVID-19 in real time // Lancet Infect. Dis. 2020. Vol. 20, № 5. P. 533–534.</mixed-citation><mixed-citation xml:lang="en">Dong E., Du H., Gardner L. An interactive web-based dashboard to track COVID-19 in real time // Lancet Infect. Dis. 2020. Vol. 20, № 5. P. 533–534.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Guan W. J., Ni Z.-Y., Hu Y. et al. Clinical characteristics of coronavirus disease 2019 in China // N. Engl. J. Med. 2020. Vol. 382, № 18. P. 1708–1720.</mixed-citation><mixed-citation xml:lang="en">Guan W. J., Ni Z.-Y., Hu Y. et al. Clinical characteristics of coronavirus disease 2019 in China // N. Engl. J. Med. 2020. Vol. 382, № 18. P. 1708–1720.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Jin X., Lian J.-S., Hu J.-H. et al. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms // Gut. 2020. Vol. 69, № 6. P. 1002–1009.</mixed-citation><mixed-citation xml:lang="en">Jin X., Lian J.-S., Hu J.-H. et al. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms // Gut. 2020. Vol. 69, № 6. P. 1002–1009.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Pan L., Mu M., Yang P. et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study // Am. J. Gastroenterol. 2020. Vol. 115, № 5. P. 766–773.</mixed-citation><mixed-citation xml:lang="en">Pan L., Mu M., Yang P. et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study // Am. J. Gastroenterol. 2020. Vol. 115, № 5. P. 766–773.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou P., Yang X.-L., Wang X.-G. et al. Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin // BioRxiv: The preprint server for biology. 23.01.2020. URL: https://www.biorxiv.org/content/10.1101/2020.01.22.914952v1. doi: https://doi.org/10.1101/2020.01.22.914952.</mixed-citation><mixed-citation xml:lang="en">Zhou P., Yang X.-L., Wang X.-G. et al. Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin // BioRxiv: The preprint server for biology. 23.01.2020. URL: https://www.biorxiv.org/content/10.1101/2020.01.22.914952v1. doi: https://doi.org/10.1101/2020.01.22.914952.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang H., Kang Z., Gong H. et al. The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes // BioRxiv: The preprint server for biology. 31.01.2020. URL: https://www.biorxiv.org/content/10.1101/2020.01.30.927806v1. DOI: 10.1101/2020.01.30.927806.</mixed-citation><mixed-citation xml:lang="en">Zhang H., Kang Z., Gong H. et al. The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes // BioRxiv: The preprint server for biology. 31.01.2020. URL: https://www.biorxiv.org/content/10.1101/2020.01.30.927806v1. DOI: 10.1101/2020.01.30.927806.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Xiao F., Tang M., Zheng X. et al. Evidence for gastrointestinal infection of SARS-CoV-2 // Gastroenterology. 2020. Vol. 158, № 6. P. 1831–1833.e3.</mixed-citation><mixed-citation xml:lang="en">Xiao F., Tang M., Zheng X. et al. Evidence for gastrointestinal infection of SARS-CoV-2 // Gastroenterology. 2020. Vol. 158, № 6. P. 1831–1833.e3.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hoffmann M., Kleine-Weber H., Schroeder S. et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor // Cell. 2020. Vol. 181, № 2. P. 271–280.e8. URL: http://www.ncbi.nlm.nih.gov/pubmed/32142651.</mixed-citation><mixed-citation xml:lang="en">Hoffmann M., Kleine-Weber H., Schroeder S. et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor // Cell. 2020. Vol. 181, № 2. P. 271–280.e8. URL: http://www.ncbi.nlm.nih.gov/pubmed/32142651.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Hung I. F. N., Cheng V. C. C., Wu A. K. L. et al. Viral loads in clinical specimens and SARS manifestations // Emerg. Infect. Dis. 2004. Vol. 10, № 9. P. 1550–1557.</mixed-citation><mixed-citation xml:lang="en">Hung I. F. N., Cheng V. C. C., Wu A. K. L. et al. Viral loads in clinical specimens and SARS manifestations // Emerg. Infect. Dis. 2004. Vol. 10, № 9. P. 1550–1557.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou J., Li C., Zhao G. et al. Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus // Sci. Adv. 2017. Vol. 3, № 11. P. eaao4966.</mixed-citation><mixed-citation xml:lang="en">Zhou J., Li C., Zhao G. et al. Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus // Sci. Adv. 2017. Vol. 3, № 11. P. eaao4966.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Holshue M. L., DeBolt C., Lindquist S. et al. First case of 2019 novel coronavirus in the United States // N. Engl. J. Med. 2020. Vol. 382, № 10. P. 929–936.</mixed-citation><mixed-citation xml:lang="en">Holshue M. L., DeBolt C., Lindquist S. et al. First case of 2019 novel coronavirus in the United States // N. Engl. J. Med. 2020. Vol. 382, № 10. P. 929–936.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Tisoncik J. R., Korth M. J., Simmons C. P. et al. Into the eye of the cytokine storm // Microbiol. Mol. Biol. Rev. 2012. Vol. 76, № 1. P. 16–32.</mixed-citation><mixed-citation xml:lang="en">Tisoncik J. R., Korth M. J., Simmons C. P. et al. Into the eye of the cytokine storm // Microbiol. Mol. Biol. Rev. 2012. Vol. 76, № 1. P. 16–32.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Perrone F., Piccirillo M. C. Tocilizumab in COVID-19 pneumonia (TOCIVID-19): Full Text View // ClinicalTrials.gov. 12.04.2020. URL: https://clinicaltrials.gov/ct2/show/NCT04317092.</mixed-citation><mixed-citation xml:lang="en">Perrone F., Piccirillo M. C. Tocilizumab in COVID-19 pneumonia (TOCIVID-19): Full Text View // ClinicalTrials.gov. 12.04.2020. URL: https://clinicaltrials.gov/ct2/show/NCT04317092.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Evaluation of the efficacy and safety of sarilumab in hospitalized patients with COVID-19: Full Text View // ClinicalTrials.gov. 12.04.2020. URL: https://clinicaltrials.gov/ct2/show/NCT04315298.</mixed-citation><mixed-citation xml:lang="en">Evaluation of the efficacy and safety of sarilumab in hospitalized patients with COVID-19: Full Text View // ClinicalTrials.gov. 12.04.2020. URL: https://clinicaltrials.gov/ct2/show/NCT04315298.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Monteleone G., Ardizzone S. Are patients with inflammatory bowel disease at increased risk for COVID-19 infection? // J. Crohns Colitis. 2020. Vol. 14, № 9. P. 1334–1336.</mixed-citation><mixed-citation xml:lang="en">Monteleone G., Ardizzone S. Are patients with inflammatory bowel disease at increased risk for COVID-19 infection? // J. Crohns Colitis. 2020. Vol. 14, № 9. P. 1334–1336.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Rubin D., Feuerstein J. D., Wang A. Y. et al. AGA clinical practice update on management of inflammatory bowel disease during the COVID-19 pandemic: expert commentary // Gastroenterology. 2020. Vol. 159, № 1. P. 350–357.</mixed-citation><mixed-citation xml:lang="en">Rubin D., Feuerstein J. D., Wang A. Y. et al. AGA clinical practice update on management of inflammatory bowel disease during the COVID-19 pandemic: expert commentary // Gastroenterology. 2020. Vol. 159, № 1. P. 350–357.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Tian Y., Rong L., Nian W. et al. Review article: gastrointestinal features in COVID-19 and the possibility of faecal transmission // Aliment. Pharmacol. Ther. 2020. Vol. 51, № 9. P. 843–851.</mixed-citation><mixed-citation xml:lang="en">Tian Y., Rong L., Nian W. et al. Review article: gastrointestinal features in COVID-19 and the possibility of faecal transmission // Aliment. Pharmacol. Ther. 2020. Vol. 51, № 9. P. 843–851.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Gutin L. S., Lam A. Y., Velayos F. S. et al. Going viral: management of IBD in the era of the COVID-19 pandemic // Dig. Dis. Sci. 2020. Vol. 65, № 6. P. 1571–1575.</mixed-citation><mixed-citation xml:lang="en">Gutin L. S., Lam A. Y., Velayos F. S. et al. Going viral: management of IBD in the era of the COVID-19 pandemic // Dig. Dis. Sci. 2020. Vol. 65, № 6. P. 1571–1575.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Y., Geng X., Tan Y. et al. New understanding of the damage of SARS-CoV-2 infection outside the respiratory system // Biomed. Pharmacother. 2020. Vol. 127. P. 110195.</mixed-citation><mixed-citation xml:lang="en">Zhang Y., Geng X., Tan Y. et al. New understanding of the damage of SARS-CoV-2 infection outside the respiratory system // Biomed. Pharmacother. 2020. Vol. 127. P. 110195.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Sabino-Silva R., Jardim A. C. G., Siqueira W. L. Coronavirus COVID-19 impacts to dentistry and potential salivary diagnosis // Clin. Oral Investig. 2020. Vol. 24, № 4. P. 1619–1621.</mixed-citation><mixed-citation xml:lang="en">Sabino-Silva R., Jardim A. C. G., Siqueira W. L. Coronavirus COVID-19 impacts to dentistry and potential salivary diagnosis // Clin. Oral Investig. 2020. Vol. 24, № 4. P. 1619–1621.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Repici A., Maselli R., Colombo M. et al. Coronavirus (COVID-19) outbreak: what the department of endoscopy should know // Gastrointest. Endosc. 2020. Vol. 92, № 1. P. 192–197.</mixed-citation><mixed-citation xml:lang="en">Repici A., Maselli R., Colombo M. et al. Coronavirus (COVID-19) outbreak: what the department of endoscopy should know // Gastrointest. Endosc. 2020. Vol. 92, № 1. P. 192–197.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Гриневич В. Б., Кравчук Ю. А., Ткаченко Е. И. и др. Особенности ведения больных с гастроэнтерологической патологией в условиях пандемии COVID-19 // Экспериментальная и клиническая гастроэнтерология. 2020. Т. 174, № 4. С. 3–18.</mixed-citation><mixed-citation xml:lang="en">Гриневич В. Б., Кравчук Ю. А., Ткаченко Е. И. и др. Особенности ведения больных с гастроэнтерологической патологией в условиях пандемии COVID-19 // Экспериментальная и клиническая гастроэнтерология. 2020. Т. 174, № 4. С. 3–18.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Guarner F. et al. World Gastroenterology Organization. World Gastroenterology Organisation Global Guidelines: probiotics and prebiotics. February 2017.</mixed-citation><mixed-citation xml:lang="en">Guarner F. et al. World Gastroenterology Organization. World Gastroenterology Organisation Global Guidelines: probiotics and prebiotics. February 2017.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Moon A. M., Webb G. J., Aloman C. et al. High mortality rates for SARS-CoV-2 infection in patients with pre-existing chronic liver disease and cirrhosis: Preliminary results from an international registry // J. Hepatol. 2020. Vol. 73, № 3. P. 705–708.</mixed-citation><mixed-citation xml:lang="en">Moon A. M., Webb G. J., Aloman C. et al. High mortality rates for SARS-CoV-2 infection in patients with pre-existing chronic liver disease and cirrhosis: Preliminary results from an international registry // J. Hepatol. 2020. Vol. 73, № 3. P. 705–708.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Gu J., Han B., Wang J. COVID-19: gastrointestinal manifestations and potential fecal-oral transmission // Gastroenterology. 2020. Vol. 158, № 6. P. 1518–1519.</mixed-citation><mixed-citation xml:lang="en">Gu J., Han B., Wang J. COVID-19: gastrointestinal manifestations and potential fecal-oral transmission // Gastroenterology. 2020. Vol. 158, № 6. P. 1518–1519.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Lan L., Xu D., Ye G. et al. Positive RT-PCR test results in patients recovered from COVID-19 // JAMA. 2020. Vol. 323, № 15. P. 1502–1503.</mixed-citation><mixed-citation xml:lang="en">Lan L., Xu D., Ye G. et al. Positive RT-PCR test results in patients recovered from COVID-19 // JAMA. 2020. Vol. 323, № 15. P. 1502–1503.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
