cmedasНепрерывное медицинское образование и наукаContinuing Medical Education and Science2949-62923033-585XAGUcmedas-57Research ArticleЛИТЕРАТУРНЫЙ ОБЗОРLITERARY REVIEWПроявления инфекции Helicobacter pylori вне системы пищеваренияManifestations of Helicobacter pylori infection outside the digestive systemСарсенбаеваА. С.SarsenbaevаA. S.

Сарсенбаева Айман Силкановна, д-р мед. наук,  профессор кафедры терапии Института  дополнительного профессионального образования

454021, г. Челябинск, ул. Островского, 81, ГБУЗ OКБ № 3; тел. +7 351 742-82-57

Chelyabinsk

kafedraterapii@mail.ruДомрачеваЕ. В.DomrachevaE. V.

Домрачева Екатерина Владимировна, канд. мед. наук,  гастроэнтеролог

Челябинск

Chelyabinsk

gastro74@mal.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Южно-Уральский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияSouth-Urals State Medical UniversityRussian FederationООО «Гастроэнтерологическая практика Уфимцева К.А.»РоссияMedical Center “Gastroenterological Practice Ufimtseva K.A.”Russian Federation2021020820231642942Copyright © Сарсенбаева А.С., Домрачева Е.В., 20232023Сарсенбаева А.С., Домрачева Е.В.Sarsenbaevа A.S., Domracheva E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cmedas.elpub.ru/jour/article/view/57

Инфекция Helicobacter pylori (H. pylori) приводит к различным заболеваниям, таким как язва желудка и двенадцатиперстной кишки, хронический гастрит и злокачественные заболевания, в том числе MALT-лимфома и рак желудка. На сегодняшний день изучены различные факторы патогенности и вирулентности бактерии H. pylori. Взаимодействие инфекции с клетками макроорганизма приводит к индукции воспалительных реакций посредством высвобождения цитокинов, активации апоптоза или пролиферации, что ведет к воспалению и нарушению функции эпителиального барьера. Этот процесс может способствовать перемещению факторов вирулентности H. pylori и медиаторов воспаления в кровоток и способствовать или усиливать развитие системного воспалительного ответа и возможные клинические эффекты инфекции H. pylori за пределами желудка. Целью данного обзора является уточнение имеющихся данных о связи инфекции H. pylori с заболеваниями сердечно-сосудистой, нервной, эндокринной систем, аутоиммунными заболеваниями и некоторыми другими патологиями вне системы пищеварения.

Helicobacter pylori (H. pylori) infection leads to various diseases such as gastric and duodenal ulcers, chronic gastritis and malignant diseases, including MALT lymphoma and stomach cancer. To date, various factors of pathogenicity and virulence of the H. pylori bacterium have been studied. The interaction of infection with host cells leads to the induction of inflammatory responses through the release of cytokines, activation of apoptosis or proliferation, which leads to inflammation and dysfunction of the epithelial barrier. This process can facilitate the movement of H. pylori virulence factors and inflammatory mediators into the bloodstream and promote or enhance the development of a systemic inflammatory response and the possible clinical effects of H. pylori infections outside the stomach. The purpose of this review is to clarify the available data on the relationship of H. pylori infection with diseases of the cardiovascular, nervous, endocrine systems, autoimmune diseases, and some other pathologies outside the digestive system.

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The authors declare that there are no conflicts of interest present.